Selenium-promoted synthesis of enantiomerically pure substituted morpholines starting from alkenes and chiral aminoalcohols

摘要

Enantiomerically pure 2,3.5-trisubstituted morpholines with two newly created stereocenters have been prepared by a short synthetic sequence caving as the key step the selenium-promoted addition of (R)-phenylglycinol to 1 substituted alkene. (C) 2003 Elsevier Ltd. All rights reserved. [References: 20]