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首页> 外文期刊>Tetrahedron, Asymmetry: The International Journal for Repid Publication on all Aspects of Asymmetry in Orgainc, Inorganic, Organometallic, Physical and Bio-Organic Chemistry >Asymmetric synthesis of (S)-4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)-l-butanol, a key intermediate for (1S,5R)-(-)-frontalin via asymmetric bromolactonization
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Asymmetric synthesis of (S)-4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)-l-butanol, a key intermediate for (1S,5R)-(-)-frontalin via asymmetric bromolactonization

机译:(S)-4-(2,2,4-三甲基-1,3-二氧杂戊-4-基)-1-丁醇的不对称合成,这是(1S,5R)-(-)-额叶蛋白的关键中间体溴化

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摘要

A asymmetric synthesis of (S)-4-(2,2,4-trimethyl-1,3-dioxolan-4-yl)-1-butanol, a key intermediate for (1S,5,R)-(-)-frontalin, via asymmetric bromolactonization employing (S)-(-)-proline as a chiral auxiliary is described. (C) 2002 Elsevier Science Ltd. All rights reserved. [References: 21]
机译:(S)-4-(2,2,4-三甲基-1,3-二氧戊环-4-基)-1-丁醇((1S,5,R)-(-)-的关键中间体)的不对称合成描述了通过使用(S)-(-)-脯氨酸作为手性助剂的不对称溴内酰胺化法制备的弗拉塔林。 (C)2002 Elsevier ScienceLtd。保留所有权利。 [参考:21]

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