Enzymatic reactions in ionic liquids: lipase-catalysed kinetic resolution of racemic, P-chiral hydroxymethanephosphinates and hydroxymethylphosphine oxides

摘要

Lipase-mediated acetylation of racemic P-chiral hydroxymethanephosphinates and hydroxymethylphosphine oxides was performed in ionic liquids under kinetic resolution conditions. Lipase AK (Amano) and lipase from Pseudomonas fluorescens (Fluka) were up to six times more enantioselective in BMIM-PF6, solutions than in common organic solvents. On the contrary, the analogous reactions performed in BMIM-BF4, were practically non-stereoselective. (C) 2002 Published by Elsevier Science Ltd. [References: 21]