Highly enantioselective organocatalytic α-selenylation of aldehydes using hypervalent iodine compounds

摘要

The highly enantioselective organocatalytic α-selenylation reaction of aldehydes using a hypervalent iodine compound as an oxidative agent from commercially available phenyl diselenide under mild oxidative conditions is described. This transformation affords α-selenyl aldehydes in good yields and with excellent enantioselectivities. By using hypervalent iodine compounds, it opens up a suitable and alternative way for the preparation of biologically active building blocks such as β-hydroxy alcohols, α-amino acids, and α-hydroxy esters.