Copper-catalyzed asymmetric propargylic amination of propargylic acetates with amines using BICMAP

摘要

The copper-catalyzed asymmetric propargylic amination of propargylic acetates 1 with amines 2 using BICMAP as a chiral ligand gave the desired products 3 in good yields and with moderate to high enantioselectivities (up to 90% ee).