A crystallization-induced asymmetric transformation to prepare (R)-4-chlorophenylalanine methyl ester

摘要

A second order asymmetric transformation of racemic 4-chlorophenylalanine methyl ester was achieved via salt formation with (2S,3S)-(-)-tartaric acid in the presence of salicylaldehyde to afford the desired (R)-enantiomer of 4-chlorophenylalanine methyl ester in good yield and high enantiomeric purity. (C) 1998 Elsevier Science Ltd. An rights reserved. [References: 18]