Catalytic enantioselective reactions. Part 18: Preparation of 3-deoxy-3-N,N-dialkylamino-1,2;5,6-di-O-isopropylidene-D-altritol derivatives from D-mannitol and their applications for catalytic enantioselective addition of dialkylzinc to aldehydes

摘要

A series of new chiral beta-aminoalcohols, 3-deoxy-3-N,N-dialkylamino- 1,2;5,6-di-O-isopropylidene-D-altritol derivatives 2-4 possessing a variety of amine substituents at the 3-position and thiol or acetylthio group at the 4-position was prepared from D-mannitol and enantioselective additions of diethylzinc to aldehydes using them as chiral catalysts were examined. (C) 2000 Elsevier Science Ltd. All rights reserved. [References: 25]