New chiral ligands, pyrrolidinyl- and 2-azanorbornylphosphinooxazolidines for palladium-catalyzed asymmetric allylation

摘要

Pyrrolidinyl-2 and 2-azanorbornylphosphinooxazolidines 3, a new type of optically active ligands, were synthesized easily and their abilities as ligands were examined in Pd-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate with dimethyl malonate. Enantiomeric excesses of up to 96% have been obtained using 1 mol% of [PdCl(eta(3)-C3H5)](2) and 2.1 mol% of 2. (C) 2000 Elsevier Science Ltd. All rights reserved. [References: 23]