Minimal Uterine Serous Carcinoma With Extrauterine Spread: An Easily Overlooked Endometrial Malignancy

摘要

Minimal uterine serous carcinoma (MUSC) includes serous endometrial intraepithelial carcinoma and superficial serous carcinoma. MUSC has the cytological and immunohistochemical profile of conventional serous carcinoma, including overexpression of the mutant p53 protein. The tumor frequently occurs in association with an endometrial polyp in patients with postmenopausal bleeding, and it may present with extrauterine disease despite intraepithelial or minimally invasive involvement within the uterus. We present the case of a 64-year-old woman who developed abdominal carcinomatosis due to high-grade miillerian carcinoma. MUSC confined to an endometrial polyp was eventually identified in the staging specimens and was the presumed origin of the patient's disease.