Anal Gland Carcinoma

摘要

Anal gland carcinoma is a rare and controversial entity. The definition is controversial in that some consider histogenesis, ie, identifying an origin from anal ducts or glands for the basis of typing, whereas others use the direction of differentiation, ie, formation of glandular structures resembling anal glands or ducts. In 2001, Hobbs et al. reported a relatively large series of 7 cases of anal gland carcinomas, describing their histologic and immunohisto-chemical features. The tumors were composed of haphazardly dispersed, small glands with scant mucin production that invaded the wall of the anorectal area with no obvious mtraluminal component. Immunohistochemically, the epithelium in all 7 cases was positive for cytokeratin (CK) 7.