Application of matrix solid phase dispersion to the determination of imidacloprid, carbaryl, aldicarb, and their main metabolites in honeybees by liquid chromatography-mass spectrometry detection

摘要

A method based on matrix solid phase dispersion (MSPD) using C18 as dispersant and dichloromethane-methanol as eluent and liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry (LC-APCI-MS) has been developed for the simultaneous determination of imidacloprid, 6-chloronicotinic acid, carbaryl, aldicarb, aldicarb sulfoxide, and aldicarb sulfone in honeybees.