首页> 外文期刊>Talanta: The International Journal of Pure and Applied Analytical Chemistry >Study on DNA damage induced by CdSe quantum dots using nucleic acid molecular'light switches'as probe
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Study on DNA damage induced by CdSe quantum dots using nucleic acid molecular'light switches'as probe

机译:以核酸分子“光开关”为探针研究CdSe量子点诱导的DNA损伤

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摘要

The calf thymus DNA(ctDNA)damage induced by water-soluble CdSe quantum dots(QDs)was investigated using nucleic acid molecular"light switches"as probe.It was found that little ctDNA was damaged by CdSe QDs without UV irradiation.However,under UV irradiation,ctDNA was nicked by CdSe QDs very clearly.The mechanism of ctDNA damage was also discussed.The results strongly suggested that the ctDNA damage caused by CdSe QDs was not due to photo-induced liberation of Cd2+,but due to the production of free radicals and reactive oxygen species.
机译:以核酸分子“光开关”为探针研究了水溶性CdSe量子点(QDs)诱导的小牛胸腺DNA(ctDNA)损伤。发现在没有紫外线照射的情况下,几乎没有ctDNA被CdSe QDs破坏。紫外线照射下,ctDNA被CdSe量子点很清楚地刻痕。还讨论了ctDNA损伤的机理。结果强烈表明,CdSe量子点引起的ctDNA损伤不是由于光诱导的Cd2 +释放,而是由于Cd2 +的产生。自由基和活性氧。

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