High-dose Misoprostol as an Alternative Therapy After Failed Medical Abortion

摘要

Objective: The aim of this study was to determine the complete abortion rate for the vaginal administration ofhigh-dose misoprostol after a failed medical abortion.Materials and Methods: When their medical abortions failed after the conventional oral administration ofmifepristone and misoprostol, participants then received 1,000mug of misoprostol vaginally. The efficacy andside effects of this treatment were evaluated.Results: Twenty-seven women who failed to abort after the conventional administration of mifepristone andmisoprostol were enrolled in this trial. Fourteen days after the vaginal administration of 1,000 mug misoprostol,the overall complete expulsion rate had reached 88.8% (24/27). Most adverse effects were mild to moderateand did not require treatment.Conclusion: The vaginal administration of 1,000 mug misoprostol as a salvage therapy after a failed medicalabortion appears to be a safe and highly effective alternative to surgical intervention.