An Albumin-Activated Far-Red Fluorochrome for In Vivo Imaging

摘要

A variety of far red (FR) and near infrared (NIR) fluorochromes have been described recently for in vivo fluorescence imaging of disease.These fluorochromes have been classified generally into nonspecific enhancers (such as ICG),molecularly targeted fluorochromes (such as RGD-Cy),and enzyme-activated agents (such as cathepsin-sensitive NIRF probes).Collectively,these agents have shown tremendous potential for the in vivo imaging of specific molecular targets,biological processes and cells.For example,specific fluorochromes have been used to image angiogenesis,apoptosis,vascular permeability,protease activity,receptor status,macrophage activity and to track cells.