Open access journals represent a new business model in the field of biomedical journal publications. PLOS OiVEbegan in 2006 and published 138 articles. It published 1200 articles in 2007. In 2011, PLOS ONE published 13,798 articles. In 2011, approximately one in 60 of all articles indexed by PubMed were published by PLOS ONE, making the publication today the largest journal in the world. There are 7706 open access journals listed in the Directory of Open Access, with almost 800,000 articles published (as of May 8, 2012). Some open access journals are indexed on MEDLINE; all open access journals are discoverable on PubMed by depositing in PubMed Central.
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