Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+Colorectal Cancer Cells

Schmohl J. U.; Gleason M. K.; Dougherty P. R.; Miller J. S.; Vallera D. A.

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Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+Colorectal Cancer Cells

机译：异二聚体双特异性单链可变片段（scFv）杀手吞噬（BiKEs）增强NK细胞针对CD133 +大肠癌细胞的活性。

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Natural killer (NK) cells are potent cytotoxic lymphocytes that play a critical role in tumor immunosurveillance and control. Cancer stem cells (CSC) initiate and sustain tumor cell growth, mediate drug refractory cancer relapse, and express the well-known surface marker CD133.

机译：天然杀伤（NK）细胞是有效的细胞毒性淋巴细胞，在肿瘤的免疫监视和控制中起着至关重要的作用。癌症干细胞（CSC）启动并维持肿瘤细胞的生长，介导药物难治性癌症的复发，并表达众所周知的表面标记CD133。

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《Targeted oncology》 |2016年第3期|共9页
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Schmohl J. U.; Gleason M. K.; Dougherty P. R.; Miller J. S.; Vallera D. A.;
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正文语种 eng
中图分类肿瘤学;
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1. Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+Colorectal Cancer Cells [J] . Schmohl J. U., Gleason M. K., Dougherty P. R., Targeted oncology . 2016,第3期

机译：异二聚体双特异性单链可变片段（scFv）杀手吞噬（BiKEs）增强NK细胞针对CD133 +大肠癌细胞的活性。
2. Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors [J] . Cheng Ming, Santich Brian H., Xu Hong, Oncoimmunology. . 2016,第6期

机译：成功的高效单链可变片段（SCFV）双特异性抗体的工程，靶向Disialoganglioside（GD2）阳性肿瘤
3. Generation and immune-characterization of single chain fragment variable (scFv) antibody recognize breast cancer cells line (MCF-7) [J] . Ilham Mahgoub, Ahmed K Bolad, Mohamed Mergani Journal for ImmunoTherapy of Cancer . 2014,第S1期

机译：单链片段可变（scFv）抗体的产生和免疫特性识别乳腺癌细胞系（MCF-7）
4. In Silico Study of Single Chain Fragment Variable (ScFv) on Chikungunya Virus Using Indonesian Strain [C] . Korry Novitriani, Shabarni Gaffar, Bacthi Alisjahbana, Bakti Tunas Husada-Health Science International Conference . 2020

机译：在使用印度尼西亚菌株的Chikungunya病毒上单链片段变量（SCFV）的硅研究
5. CD16xCD33 bispecific killer cell engager (BiKE) activates natural killer (NK) cells from myelodysplastic syndrome (MDS) patients against primary MDS and myeloidderived suppressor cell (MDSC) CD33-positive targets. [D] . Gleason, Michelle K. 2014

机译：CD16xCD33双特异性杀伤细胞接合剂（BiKE）激活来自骨髓增生异常综合征（MDS）患者的自然杀伤（NK）细胞，以抵抗原发性MDS和髓样抑制细胞（MDSC）CD33阳性靶标。
6. Heterodimeric bispecific single chain variable fragments (scFv) killer engagers (BiKEs) enhance NK-cell activity against CD133+ colorectal cancer cells [O] . Schmohl JU, Gleason MK, Dougherty PR, -1

机译：异二聚体双特异性单链可变片段（scFv）杀伤分子（BiKEs）增强NK细胞针对CD133 +大肠癌细胞的活性
7. Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+ Colorectal Cancer Cells [O] . J. U. Schmohl, M. K. Gleason, P. R. Dougherty, 2015

机译：异二聚体双特异性单链可变片段（SCFV）杀手烘焙器（自行车）增强针对CD133 +结肠直肠癌细胞的NK细胞活性

Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+Colorectal Cancer Cells

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