Rhodium mediated C-H Bond functionalisation leading to carboxylate: Derivatives

摘要

Selective functionalisation of 15-cyclooctadiene either to a carboxylic acid or to a γ-lactone is achieved by a novel sequence of reactions involving quantitative oxygenation with oxygen and C-C coupling with carbon monoxide (see graphic). The rhodium hydroxy-alkyl-allyl complex shown is the active intermediate that promotes the elimination of the organic compounds.