Covalently Bonded Platinum(II) Complexes of #alpha#-Amino Acids and Peptides as a Potential Tool for Protein Labeling

摘要

Arylplatinum(II) complexes have been covalently bonded to the N and C termini and to the #alpha#-carbon of various amino acid derivatives. These organometallic-functionalized amino acid compounds can be converted into the corresponding free amino acids under both basic and acidic conditions; this demonstrates the excellent stability properties of these biomolecules. Due to the NMR activity displayed by the ~(195)Pt nucleus (natural abundance 33.8%, I = 1/2) these compounds are functional biomarkers. Furthermore, the ability of the arylplatinum functional group t bind SO_2 gas, selectively and reversibly as indicated by changes in the spectroscopic properties (~1H, ~(13)C, ~(195)Pt NMR and UV spectra) of these compounds, allows for the potential use of these complexes as in vitro biosensors.