Synthesis of biodegradable poly(propylene fumarate)networks with poly(propylene fumarate0-diacrylate macromers as crosslinking agents and characterization of their degradation products

摘要

New biodegradable poly(propylene fumarate)-based polymer networks have been prepared by radical polymerization using p0k :~n~-lene fumarate (PPF and polv(propvlene fumarate—diacrvlate PPF—DA macminers. Two PPF—DAs s~ere synthesized incorporaung c~I and t~o on fuindrate unit~. and were ernplo~ed in the ~‘,n, es~s of the oolvrner ner~~ orks. The PPF/PPF—DA double ~nd r~o and the molecular weijit of PPF—DA were ‘aned ~o assess eir etTec~ on the ~ ann.. pm ~ ...es of die resulting polYmer nev~ioxks as u~N as Wi ~w apm~dmii ~ ~m The c~~ei~e ~engtn at fr~e ot P?F PP~-DA vim = I vmer networks increased from·i1 WIW’W—IM 4,in I~ ~cxmaI ~mn 4 to 05 An increase in compressi e~tIb~ &IUIfr huid raiio of PPFJPPF-DA. Increasing x ~u mid ,ncduhis o( ibe corresponding po1~ix~ networks to increase to the r~ps 4~I4.4 ± 4.ZuiB.2 ~ 64 Wa id ~ 2A w 4~).4 359 MPa,, respectively. Similarly. ~xh wereincreased as the PPF/PPF—DA (m =2) ~~oble bond ralio decreased fnm 4 to OS. The PFFIPPF-DA crosslinked polymer networks s&w~ negligible equilibrium water content for all 10 formulations tested in this snid.. The degradation reaction of the PPF/PPF—DA poIs.m networks under basic conditions was investigated. The degradation products were isolated and characterized by NMR and GUNIS a~acid, propylene glycol, and poly(acmylic acid-co-fumaric acid) of weight average molecular weight of 5080. These data denmnsir~ ~ biodegradable PPF/PPF—DA polymer networks should have great potential as polymer scaffolds for orthopedic applications engineering.