Ligand Selection in RuII Complexes for Direct One-Electron Photooxidation of Guanine: A Combined Computational and Experimental Study

摘要

The study of the photoreactivity of transition-metal complexes with nucleic acids has become a major field of research over the last 20 years. Depending on their photophysical and photochemical properties, which can easily be tuned by the type of ligands and nature of the metallic center, these complexes can be used as very effective anticancer agents.[1, 2] Their therapeutic activity is generally linked to their reactivity with nucleic acids, which results in photoadduct formation with a covalent bond between the metallic compound and a DNA base, or, to a lesser extent, DNA cleavage.[1, 3C5] Among the most promising metal-based antitumor drugs, ruthenium complexes are under intensive investigation to design highly active drugs with low toxicity.[ 2]