No change in small molecule transport with prolonged embedding of peritoneal dialysis catheters.

摘要

We read with interest the article by Flessner and colleagues and were intrigued by the findings in Wistar rats of a significantincreasein peritonealinflammation with a dormant silicone peritoneal catheter compared with a peritoneal catheter that was used to inject solution (1). Our program routinely uses embedded peritoneal catheters inserted months before the need for dialysis. Our mechanical and infectious outcomes have been published previously, but these results prompted us to look for any relationship between baseline peritoneal small molecule transport and duration of time the catheter was embedded prior to use (2,3). We chose to look at the dialysate-to-plasma creatinine (D/P Cr) ratio at 4 hours with a standard peritoneal equilibration test (PET) as some groups have shown a relationship between higher D/P Cr and increased levels of effLuent inflammatory markers (4).