The influence of duration of peritoneal dialysis therapy on the outcomes of initial and subsequent peritonitis is different

摘要

The number of patients with a longer peritoneal dialysis (PD) duration is currently growing because of improved survival rates worldwide. To our knowledge, a longer PD duration is associated with alterations of the peritoneal membrane and peritoneal macrophages (1), potentially decreasing the immune defense against peritonitis. However, the current evidence on this issue is conflicting. Earlier studies have reported thata longer PD duration predicts worse (2,3) or better (4) peritonitis outcomes or has no effect (5,6).