Macrocyclic Glycoclusters:From Amphiphiles through Nanoparticles to Glycoviruses

摘要

Macrocyclic glycocluster amphiphiles are intended to be a covalent-bundle mimic of clustering gly-colipid motifs on the cell membrane.They are irreversibly micellized to give glycocluster nanoparticles(GNPs);their masked hydrophobicity endows them with remarkable saccharide specificities in the interactions with biological saccharide receptors.The GNPs also exhibit unprecedented hydrogen-bond capacities; they are agglutinated with Na_2HPO_4 and assembled on plasmid DNA in a number-,size-,and shape-controlled manner to give artificial glycoviral particles capable of transfection.Thus,the intrinsic function of viruses,that is,cell invasion followed by gene expression,is also intrinsic to size-regulated(~50nm)glycoviruses.The growth of glycocluster amphiphiles through nanoparticles to glycoviruses reveals a hierarchical adhesion control of the saccharide clusters.