PREDICTING THE PERITONEAL ABSORPTION OF ICODEXTRIN IN RATS AND HUMANS INCLUDING THE EFFECT OF alpha-AMYLASE ACTIVITY IN DIALYSATE

摘要

Background: Contrary to ultrafiltration, the three-pore model predictions of icodextrin absorption from the peritoneal cavity have not yet been reported likely, in part, due to difficulties in estimating the degradation of glucose-polymer chains by a-amylase activity in dialysate. We incorporated this degradation process in a modified three-pore model of peritoneal transport to predict ultrafiltration and icodextrin absorption simultaneously in rats and humans.