SYSTEMIC AND INTRAPERITONEAL INTERLEUK1N-6 SYSTEM DURING THE FIRST YEAR OF PERITONEAL DIALYSIS

摘要

Objective:To investigate if intra peritonea I and systemic interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) are related to each other and to peritoneal solute transport rate (PSTR).Design: Longitudinal study in retrospectively selected patients.Setting: Peritoneal dialysis (PD) unit of a university-based hospital.Patients and Methods: 31 PD patients on treatment with conventional glucose-based solutions participated in a longitudinal study. IL-6 and sIL-6R were measured in plasma and overnight effluent, both at baseline and after 12 ? 2 months on PD. C-reactive protein (CRP) and serum albumin were used as surrogate markers of inflammation. PSTR of small solutes was evaluated using the dialysate-to-plasma ratio (D/P) of creatinine after a 4-hour dwell; PSTR of large solutes was evaluated using the 24-hour D/P ratio of albumin.