首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >High-density lipoprotein cholesterol and left ventricular mass index in peritoneal dialysis.
【24h】

High-density lipoprotein cholesterol and left ventricular mass index in peritoneal dialysis.

机译:腹膜透析中高密度脂蛋白胆固醇和左心室质量指数。

获取原文
获取原文并翻译 | 示例
           

摘要

OBJECTIVE: The prevalence of left ventricular hypertrophy (LVH) reaches 75% in patients with end-stage renal disease. In patients on peritoneal dialysis (PD), some factors, such as hypertension, volume overload, serum albumin, and residual renal function, have been reported to be related to LVH. Dyslipidemia often occurs in PD but it remains unclear whether dyslipidemia is related to LVH. We investigated the relationship between clinical parameters, including lipid profile, and left ventricular mass index (LVMI). METHODS: In this cross-sectional study, 34 patients undergoing PD for more than 1 year without combined therapy with hemodialysis were included. We recorded the patients' clinical data and related those parameters with LVMI as evaluated by echocardiography. RESULTS: The patients included 23 males and 11 females (age 62.2 +/- 12.1 years, duration on PD 31.6 +/- 15.6 months). Mean LVMI was 142 +/- 37 g/m2. In univariate analysis, urine volume (r = -0.493, p = 0.003), total cholesterol (r = -0.418, p = 0.01), high-density lipoprotein cholesterol (HDL-C; r = -0.374, p = 0.02), and human atrial natriuretic peptide (hANP; r = 0.600, p < 0.001) significantly correlated with LVMI. Stepwise multiple regression analysis showed that hANP (beta = 0.524, p = 0.001) and HDL-C (beta = -0.422, p = 0.007) were independently associated with LVMI (r2 = 0.32). CONCLUSION: Strict volume control and salt restriction is essential for prevention of LVH. The role of HDL-C in the development of LVH in PD patients remains to be determined.
机译:目的:终末期肾脏疾病患者左心室肥大(LVH)的患病率达到75%。据报道,在进行腹膜透析(PD)的患者中,某些因素(例如高血压,容量超负荷,血清白蛋白和残余肾功能)与LVH有关。血脂异常常发生在PD中,但尚不清楚血脂异常是否与LVH有关。我们调查了临床参数之间的关系,包括脂质分布和左心室质量指数(LVMI)。方法:在这项横断面研究中,纳入了34例行PD超过1年且未与血液透析联合治疗的患者。我们记录了患者的临床数据,并通过超声心动图评估了这些参数与LVMI的相关性。结果:患者包括23例男性和11例女性(年龄62.2 +/- 12.1岁,PD持续时间31.6 +/- 15.6个月)。 LVMI平均为142 +/- 37 g / m2。在单变量分析中,尿量(r = -0.493,p = 0.003),总胆固醇(r = -0.418,p = 0.01),高密度脂蛋白胆固醇(HDL-C; r = -0.374,p = 0.02),人心钠素(hANP; r = 0.600,p <0.001)与LVMI显着相关。逐步多元回归分析显示,hANP(β= 0.524,p = 0.001)和HDL-C(β= -0.422,p = 0.007)与LVMI独立相关(r2 = 0.32)。结论:严格控制体积和限制盐分对预防LVH至关重要。 HDL-C在PD患者LVH发生中的作用尚待确定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号