Generation and Use of an Equivalent of Difluoroacetamide or Difluoroacetate Anions

摘要

Ethers of trifluoroacetaldehyde hemiaminals can undergo dehydrofluori-nation under basic conditions to provide ethers of difluoroketene hemiaminals. The latter behave as equivalents of difluoroacetamide or difluoroacetate anions towards various electrophiles, yielding a range of difluoromethylcarbonyl products.