Veterans Affairs Cooperative Studies Program Study 553: Chemotherapy After Prostatectomy, a Phase III Randomized Study of Prostatectomy Versus Prostatectomy with Adjuvant Docetaxel for Patients with High-Risk, Localized Prostate Cancer

摘要

Radiotherapy and prostatectomy are the most commonly used primary therapies for patients with clinically localized prostate cancer.6 To better predict the efficacy of therapy, various nomograms and predictive tools have been developed and validated. The pretreatment prostate-specific antigen (PSA) level, clinical stage, and Gleason score remain the primary components of these instruments, which attempt to predict the likelihood of cure, as defined by the ability to suppress and maintain low levels of PSA without systemic therapy.