Formal Highly Enantioselective Organocatalytic Addition of Alkyl Anions to a,b-Unsaturated Aldehydes: Application to the Synthesis of Isotope- Enantiomers

摘要

During the last decade, chemists have devoted much effort to the development of new asymmetric methodologies to build complex scaffolds in a highly enantioselective fashion.[ 1] Among the strategies employed, organocatalysis[2] has received widespread attention due to its unique properties such as metal-free environment, easy predictability of stereoselectivity, use of inexpensive catalysts, and simplicity of reaction conditions.