Gold-Catalyzed [4C+3C] Intramolecular Cycloaddition of Allenedienes:Synthetic Potential and Mechanistic Implications

摘要

Transition-metal-catalyzed cycloadditions are among themost powerful methods for rapidly assembling polycyclic products from simple acyclic precursors.[1]We recently reported a Pt-catalyzed[4C+3C]cycloaddition betweendienes and tethered allenes,a transformation that provides a short and stereoselective route to synthetically useful bicycloACHTUNGTRENUNG[5.3.0]decane skeletons. The reaction proceeds with10 mol% of PtCl2,but typically requires heating at elevated temperatures(110 8C)for efficient conversions.[2]