Novel Resorcin[4]arenes as Potassium-Selective Ion-Channel and Transporter Mimics

摘要

A series of novel resorcin[4]arenes with extended #pi# systems have been synthesised and developed as potassium-selective transporters.Resorcin[4]arenes that feature crown ether moieties function as effiicient carriers of K~+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5).Incorporation of functionalities suitable for pore formation,in addition to an extra annulus of aromatic residues,gives molecules which have remarkaboe ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K~+/Na~+ selectivity.