What the Heck? Generic protocols and the development of catalytic reactions

摘要

The concept and evolutionary development of a generic protocol to give a fit-for-purpose and/or proof of transformation for a common transition metal catalysed reaction is discussed. The case for such protocols as the basis for further development and optimisation of these challenging reactions is presented. The use of advanced statistical techniques (DoE/PCA) to ensure the efficient planning of experimental designs and the effective interpretation of experimental results is outlined. The benefits of a custom-designed laboratory to support research and development in the field of metal catalysis are also highlighted. This combined approach can provide significant benefit for similar transition metal catalysed reactions, and indeed many other reactions.