Fluorine: the new kingpin of drug discovery

摘要

The benefit of introducing fluorine into pharmaceuticals has been widely recognized. This thus leads to an urgent demand of capable protocols that enable fluorination and fluoroalkylations with high efficacy and selectivity. Although challenges remaia significant progress has been made over the pa-st three decades, thereby allowing efficient incorporation of fluorine into complex organic molecules. Covering a brief history of fluorine chemistry and its association with pharmaceutical chemistry, this article reviews what the authors consider the state of the art in the field of synthetic organofluorine chemistry.