Oral nanocrystal products and nanorube drug delivery

摘要

Nanotechnologies have gained substantial interest in pharmaceutical sciences and also for the pharmaceutical industry during the last decade. New nano-scale drug delivery approaches have helped to cure diseases in a better way than before. Oral nanocrystal formulations with particle sizes in the submicron range (a few 100 nm) developed for several poorly water soluble drugs during the past decade were brought successfully to the market. These products are characterized by dissolution rate iimited absorption and manufactured by fop-down milling technologies. In contrast to non-oxidized multi-walled carbonanotubes (MWCNTs), clay mineral nanotubes are naturally occurring biocompatible, multi-walled nano-containers, having found recently broad interest in multiple technical fields, e.g.for self-repairing anticorrosion coatings, conductive and paramagnetic coatings, as biomimetic nanoreactors for bone tissue regeneration etc. and more recently also in classical pharmaceutical fields like taste masking and sustained drug release applications. The article gives an overview about oral nanocrystal products and tries to capture current trends in the field of pharmaceutical applications of nanotubes.