Improvement of cognitive dysfunction with high-dose rivastigmine.

摘要

TO THE EDITOR: The presence of neuropsychiatric symptoms in Alzheimer's disease (AD) is associated with faster cognitive and functional decline, and rivastigmine provides significant benefits in patients with AD.1 We describe the case of a 72-year-old female patient with AD who had been treated with high-dose rivastigmine, 36 mg/day, by mistake, over the previous 4 months. During this period, we observed a dramatic improvement in both cognitive status and neuropsychiatric symptoms.