Application of a light scattering microtiter plate-based method for the detection of the excipient- mediated drug precipitation inhibition

摘要

Inhibition of drug precipitation using excipients is classically determined by the quantification of the dissolved compound in the solution. Herein, a light scattering microtiter plate-based method based on the quantification of the compound precipitate was used for this purpose as an alternative methodology. By measuring light scattering in supersaturated solution the screening of 23 excipients on the precipitation inhibition of poorly soluble fenofibrate and dipyridamole was performed.