Carryover and occupational exposure limits: can they be correlated?

摘要

Tne point-of-departure for calculating a carryover limit (toxicity and pharmacology) can be the same as the one used for calculating occupational exposure limits (OEL). We calculated carryover limits with three different approaches for the purpose of comparing them to their respective OELs and assessing possible correlations. We selected several drug substances with different mechanisms of action. Calculating carryover limits from LD_(50) (LDDE) resulted consistently in much higher values than with other methods. Comparison of the OELs and permissible daily exposures (PDEs) has revealed no constant relation between the values, because there was a difference in the point-of-departure used for calculation, as well as in the use of different safety factors for different target populations (e.g. patients, employees). Looking at the log values we found a significant correlation (calculated after Pearson) between PDE and OEL and PDE and carryover value (COV). LDDE has shown the least similarity to all other values. Most similarities were found between PDE and COV.