Peptides that target protein-protein interactions as an anti-parasite strategy

摘要

Parasitic diseases are responsible for significant morbidity and mortality among vulnerable populations in developing countries where poor sanitation and lack of access to health care foster disease transmission. Current drugs are not sustainable for long-term treatment due to high toxicity, resistance issues, prohibitive prices, or inadequate methods of administration. There is an urgent need for new therapeutics that will address these issues. This mini-review discusses the potential of targeting therapeutically relevant protein-protein interactions with peptide inhibitors as anti-parasite drugs.