Selective synthesis of fluorinoted compounds on Kilogram scale Methodology and equipment

摘要

Fluorinated molecules are increasingly used in the pharma and crop protection industry. This is due to the fact that strategically placed fluorine atoms often have a positive influence on the biological properties of active compounds (1). For this reason synthetic methods for the selective preparation of specifically fluorinated intermediates and building are of high importance. Today, many fluorinated molecules are commercially available and can be used as building blocks for the synthesis of the desired fluorinated target molecule. In addition, a plethora of methods exist to selectively fluorinate a variety of substrate classes. However, in many cases either very toxic or otherwise dangerous reagents are needed, calling for particular know how and experience as well as specially equipped laboratories and reaction vessels. In this contribution we would like to discuss two aspects: i) The scope of selected fluorination methodologies and ii) the question of outsourcing the preparation of up to kg quantities of fluorinated intermediates to a specialized contractor such as Solvias.