Libraries of conformationally restricted and rigid amino acids

摘要

Libraries of rigid and conformationally restricted alpha-amino acids have good perspectives to obtain peptide models and peptidomimetics.Two mini-libraries of alpha-amino acids have been developed:one consisting of bicyclic proline analogues,another composed of potential glutamate receptor ligands containing spiro [3.3] heptane scaffold.Synthesis of some rigid amino acids using "chiral pool" terpenoids as starting compounds is also described.