Microwave-assisted palladium(II)-catalyzed Heck reactions

摘要

During the last couple of years we have reported on a number of microwave promoted oxidative Heck reactions with the aim of developing efficient and environmentally benign procedures. The use of microwave irradiation has enabled us to drastically improve reaction rates and to use substrates which are virtually unreactive at lower temperatures. A few multi-gram scale batch reactions have also been successfully executed. Several different oxidants for regeneration of palladium(II) have been evaluated from which air is the most attractive due to its low-cost, ease-of-use and low environmental impact. The use of air as palladium reoxidant was made possible by employing biaentate nitrogen ligands.