Why p-Cymene? Conformational Effect in Asymmetric Hydrogenation of Aromatic Ketones with a eta(6)-Arene/Ruthenium(II) Catalyst

摘要

The global reaction route mapping (GRRM) methods conveniently define transition states in asymmetric hydrogenation and transfer hydrogenation of aromatic ketones via the [RuH{(S,S)-TsNCH(C6H5)CH(C6H5)NH2}((6)-p-cymene)] intermediate. Multiple electrostatic CH/ interactions are the common motif in the preferred diastereometric structures.