Schizophrenia: an association study targets phospholipase A2 genes as potential sites of susceptible genes.

摘要

Schizophrenia has been associated with various abnormalities in neuronal membrane phospholipids (Peet and Stokes, 2005). Phos-pholipase A2 (PLA2) is crucial to phospholipid hydrolysis (Dennis, 1994). Five subtype enzymes are included, secreted PLA2s (sPLA2), cytosolic PLA2s (cPLA2), Ca~2+ independent PLA2s (iPLA2), platelet-activating factor acetylhydrolase (PAF-AH), and lysosomal PLA2s (Schaloske and Dennis, 2006).Studies have detected a role for PLA2 in schizophrenia (Gattaz et al. 1987; 1995; Ross et al., 1997; Barbosa et al, 2007), but findings have been inconsistent. Other susceptible genes such as PLA2G4A, PLA2G6A and PLA2C4C have been noted (Law et al., 2006; Yu et al., 2005). PLA2G7 encodes for PAF-AH (EC 3.1.1.47), which catalyzes the degradation of PAF and produces the biologically inactive products LYSO-PAF and acetate. PNPLA8 recodes patatin-like phospholipase; it can cleave phospholipid by catalyzing the hydrolysis of the sn-2 position of glycerophospholipids, phosphatidylserine and to a lesser extent phosphatidylcholine.