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Event-related brain potentials reflect increased concentration ability after mindfulness-based cognitive therapy for depression: A randomized clinical trial

机译:事件相关的脑电势反映了基于正念的抑郁症认知治疗后专注力增强:一项随机临床试验

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Mindfulness-based cognitive therapy (MBCT) effectively prevents relapse/recurrence in major depression. The ability to deploy and maintain attention on a particular focus is considered as a prerequisite for 'mindful', 'metacognitive' awareness, and hence crucial for therapy success. Accordingly, sustained concentration is the skill most extensively taught in MBCT. The goal of the present study was to test whether this ability increases after MBCT, as assumed. The late component of the contingent negative variation (CNV), an event-related brain potential (ERP), known to reflect the allocation of attentional resources, was used as the measure of concentration ability. In the main phase of the study, 91 recurrently depressed patients in remission were randomly assigned to eight-week treatment by either MBCT or waiting (WAIT for delayed MBCT). The CNV response to an auditory test stimulus was measured pre- and post-treatment in a 'mindfulness task', in which patients were instructed to focus on their breath, as taught in MBCT. The late CNV (LCNV) was increased only after MBCT (and not after WAIT). This result reflects patients' improved ability to shift their attention toward current moment experience and away from potentially depressogenic thinking or rumination during mild dysphoric states-a known risk factor for depressive relapse/recurrence.
机译:基于正念的认知疗法(MBCT)可有效预防重度抑郁症的复发/复发。在一个特定的焦点上部署和保持注意力的能力被认为是“正念”,“元认知”意识的前提,因此对于治疗成功至关重要。因此,持续专注是MBCT中最广泛教授的技能。如假定的那样,本研究的目的是测试该能力在MBCT后是否增加。或有负变化(CNV)的后期部分,即事件相关的脑电势(ERP),已知能反映注意力资源的分配,被用作集中能力的量度。在研究的主要阶段,通过MBCT或等待(等待MBCT延迟治疗)将91例复发缓解的复发性抑郁患者随机分配为八周治疗。治疗前和治疗后在“正念任务”中测量CNV对听觉测试刺激的反应,如MBCT所述,指导患者注意呼吸。晚期CNV(LCNV)仅在MBCT后才增加(而不是在WAIT之后)。该结果反映出患者在轻度烦躁不安状态下将注意力转移到当下的经验上的能力提高了,而不再是潜在的抑郁症思维或反省,这是抑郁症复发/复发的已知危险因素。

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