Amitriptyline HCI2%, Ketamine HCI5%, and Lidocaine HCI 5% in Pluronic Lecithin Organogel

摘要

Method of Preparation: Note-The lecithin:isopropyl palmitate solution can be prepared by mixing 0.2 g of sorbic acid, 50 g of soy lecithin, and 50 g of isopropyl palmitate. The Pluronic F127 solution can be prepared by mixing 0.2 g of potassium sorbate, 30 g of Pluronic F127, and sufficient purified water to make 100 mL. Calculate the required quantity of each ingredient for the total amount to be prepared. Accurately weigh or measure each ingredient. Mix the active ingredients in the ethoxydiglycol until smooth. Incorporate the lecithin:isopropyl palmitate solution and mix well. Add sufficient Pluronic F127 30% gel to volume and mix thoroughly, using a mechanical shearing force. Package and label.