Efficient gold(I) catalysed asymmetric hydroamination of alkenes

摘要

The hydroamination of alkenes is an atom-economical chemical reaction which allows the direct synthesis of various cyclic or acyclic amines of interest. However, because harsh reaction conditions are generally required, gold catalysed hydroamination of alkenes has been scarcely applied for the synthesis of chiral amines. Recent publications in this field are highlighted in order to underline the usefulness of some readily available gold catalysts for the asymmetric hydroamination of alkenes in inter-and intramolecular fashions using mild reaction conditions.