SELECTIVE AND NON-EXTRACTIVE SPECTROPHOTOMETRIC DETERMINATION OF CEFDINIR IN FORMULATIONS BASED ON DONOR-ACCEPTOR COMPLEX FORMATION

摘要

Cefdinir has broad spectrum of activity and high prescription rates, hence its counterfeiting seems imminent. We have proposed a simple, fast, selective and non-extractive spectrophotometric method for the content assay of cefdinir in formulations. The method is based on complexation of cefdinir and Fe under reducing condition in a buffered medium (pH 11) to form a magenta colored donor-acceptor complex (lambda(max) = 550 nm; apparent molar absorptivity = 3720 L mol(-1) cm(-1)). No other cephalosporins, penicillins and common excipients interfere under the test conditions. The Beer's law is followed in the concentration range 8-160 mu g mL(-1).