METABOLISMO, OXIDACAO E IMPLICACOES BIOLOGICAS DO ACIDO DOCOSAHEXAENOICO EM DOENCAS NEURODEGENERATIVAS

摘要

Docosahexaenoic acid (C22:6. n-3. DHA) is a polyunsaturated fatty acid (PUFA) present in largrge concentrations in the brain and. cue to the presence of six double bonds in its structure, is highly susceptible to oxidation by enzymes and reactive oxygenitrogen species, The perm idation of PUFAs has been implicated in an increasing number of human disorders, including neurodegenerative diseases. Hence, a better understanding of the metabolism pathways of Dl IA should provide new insights about its role in neurodegenerative diseases. Here we review the main aspects related to DHA metabolism, as well as. the recent findings showing its associationneurodegenerative diseases.