Influence of pH on the physico-chemical, thermal and mechanical properties of poly(vinyl alcohol)/poly(acrylic acid)/acyclovir films [Influência do pH nas propriedades físico-químicas, térmicas e mecanicas de filmes de poli(vinil álcool)/ poli(ácido acrílico)/aciclovir]

摘要

Drug-loaded films represent an alternative method for the treatment of skin lesions caused by Herpes simplex, since they facilitate delivery of the drug directly at the site of lesion. The objective of this work was to prepare PVA/PAA films containing AC at pH 2.0 and 4.0. The results show that the pH of the film preparations influences the polymer=drug interaction kinetic order and the degree of swelling. The mechanism of release of AC from the films obtained at pH 4.0 was anomalous, whereas for the films prepared at pH 2.0 the release followed zero-order kinetics.