STEROIDAL AND PHENOLIC COMPOUNDS FROM Sidastrum paniculatum (L.) FRYXELL AND EVALUATION OF CYTOTOXIC AND ANTI-INFLAMMATORY ACTIVITIES

摘要

Sidastrum paniculatum (L.) Fryxell belongs to the family Malvaceae and is popularly known as "malva roxa" or "malvavisco". The phytochemical study of the hexane, CHCI_3. and EtOAc phases from the crude ethanol extract of S. paniculatum led to the isolation of six compounds: a mixture of β-sitosterol and stigmasterol, 4-methoxy-3-hydroxybenzoic acid, 4-methoxy-3-hydroxybenzaldehyde, N-trans-feruloyltyramine and kaempfero1-3-O-β-D-(6"-E-p-coumaroyL) glucoside. The structural identification of the compounds was made on the basis of spectroscopic methods such as IR, 'H and '1C NMR with the aid of including two-dimensional techniques, besides comparison with literature data. The β-sitosterol and stigmasterol mixture showed a significant anti-inflammatory activity.